Description

4-(Difluoromethyl)Pyrimidine-2-Carbonitrile is a high-value, fluorinated pyrimidine derivative serving as a critical synthetic intermediate in advanced organic chemistry. Its unique structure, featuring both a difluoromethyl group and a nitrile moiety, makes it an essential building block for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting metabolic and central nervous system disorders.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance biological activity and metabolic stability.
• Material Science: Serves as a monomer or functionalizing agent for creating specialty polymers and liquid crystals with specific electronic or optical properties.
• Chemical Synthesis: Versatile building block for constructing more complex heterocyclic compounds and fluorinated analogs in medicinal and process chemistry.
• Bioconjugation & Probe Development: The reactive nitrile group allows for its use in creating biochemical probes and diagnostic agents for research applications.

Basic Information

Product Name	4-(Difluoromethyl)Pyrimidine-2-Carbonitrile
CAS No.	1416821-61-8
Molecular Formula	C6H3F2N3
Molecular Weight	155.11 g/mol
Synonyms	2-Cyano-4-(difluoromethyl)pyrimidine; 4-(Difluoromethyl)-2-pyrimidinecarbonitrile; Pyrimidine-2-carbonitrile, 4-(difluoromethyl)-; 1416821-61-8
EINECS	Contact for details

Quality Control

Every batch of 4-(Difluoromethyl)Pyrimidine-2-Carbonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and development applications. A detailed Certificate of Analysis (COA), including results from HPLC, NMR, and mass spectrometry, is available for each lot to guarantee identity, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.