Description

(S)-Ethyl 2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(2H-Tetrazol-5-Yl)Propanoate is a specialized Fmoc-protected amino acid derivative, a critical building block in modern solid-phase peptide synthesis (SPPS). Its value lies in the unique combination of the acid-labile Fmoc protecting group and the versatile, acidic tetrazole moiety, which can serve as a bioisostere for carboxylic acids or participate in click chemistry. This compound is essential for researchers and manufacturers in pharmaceutical development, particularly for creating peptide-based therapeutics, diagnostic agents, and novel chemical entities where precise control over side-chain functionality is required.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid building block for the controlled incorporation of a tetrazole functional group into peptide chains.
• Pharmaceutical Intermediates: Synthesis of active pharmaceutical ingredients (APIs) and drug candidates featuring tetrazole pharmacophores, known for enhancing metabolic stability and bioavailability.
• Chemical Biology & Proteomics: Tool compound for synthesizing peptide probes, enzyme inhibitors, and labeled peptides for biological studies.
• Bioconjugation & Linker Chemistry: Utilized in the development of peptide-drug conjugates (PDCs) and bioconjugates due to the reactive nature of the tetrazole group.
• Material Science & Polymers: Precursor for synthesizing functionalized polymers and smart materials with peptide-based recognition elements.
• Academic & Industrial R&D: Fundamental research reagent for exploring new synthetic methodologies and structure-activity relationships (SAR) in medicinal chemistry.

Basic Information

Product Name	(S)-Ethyl 2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(2H-Tetrazol-5-Yl)Propanoate
CAS No.	1416445-14-1
Molecular Formula	C21H21N5O4
Molecular Weight	407.43 g/mol
Synonyms	Fmoc-(S)-3-(2H-Tetrazol-5-yl)-alanine ethyl ester; Fmoc-3-(2H-Tetrazol-5-yl)-L-alanine ethyl ester; Ethyl (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(2H-tetrazol-5-yl)propanoate; (S)-2-(Fmoc-amino)-3-(tetrazol-5-yl)propionic acid ethyl ester; Fmoc-L-3-(2H-Tetrazol-5-yl)alanine ethyl ester; Fmoc-Tetrazole-Ala-OEt; Fmoc-3-(2H-Tetrazol-5-yl)-Ala-OEt
EINECS	Contact for details

Quality Control

Our (S)-Ethyl 2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(2H-Tetrazol-5-Yl)Propanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation, to ensure it meets the high-purity standards required for sensitive pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.