Description

6-Amino-7-[(Tetrahydro-3-Furanyl)Oxy]-4(3H)-Quinazolinone CAS NO 1405180-57-5 is a high-purity, advanced pharmaceutical intermediate belonging to the quinazolinone class of heterocyclic compounds. This compound is of significant commercial interest for its role as a critical building block in the synthesis of novel, targeted therapeutic agents. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of small-molecule drugs, particularly in oncology and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel quinazolinone-based active pharmaceutical ingredients (APIs).
• Oncology Drug Discovery: Used in research and development for creating potential kinase inhibitors and other targeted cancer therapies.
• Chemical Synthesis Building Block: Provides the core quinazolinone scaffold for medicinal chemistry programs aiming to develop new bioactive molecules.
• Biochemical Research: Employed in academic and industrial labs for studying enzyme interactions and structure-activity relationships (SAR).
• Process Development & Scale-up: Supplied in quantities suitable for process optimization, from laboratory to pilot plant scale.

Basic Information

Item	Detail
Product Name	6-Amino-7-[(Tetrahydro-3-Furanyl)Oxy]-4(3H)-Quinazolinone
CAS No.	1405180-57-5
Molecular Formula	C₁₂H₁₃N₃O₃
Molecular Weight	247.25 g/mol
Synonyms	6-Amino-7-(tetrahydrofuran-3-yloxy)quinazolin-4(3H)-one; 7-[(Tetrahydro-3-furanyl)oxy]-6-amino-4(3H)-quinazolinone; 6-Amino-7-(oxolan-3-yloxy)-3,4-dihydroquinazolin-4-one; ATFQ; Quinazolinone derivative 1405180-57-5; 6-Amino-7-(3-tetrahydrofuranyloxy)-4(3H)-quinazolinone
EINECS	Contact for details

Quality Control

Our 6-Amino-7-[(Tetrahydro-3-Furanyl)Oxy]-4(3H)-Quinazolinone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.