Description

2-{[(tert-Butoxy)Carbonyl]Amino}-3-(Pyrimidin-2-Yl)Propanoic Acid is a protected amino acid derivative featuring a pyrimidine heterocycle and a tert-butoxycarbonyl (Boc) protecting group. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, offering precise control over molecular architecture. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and bioactive molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the solid-phase and solution-phase synthesis of peptide-based drug candidates targeting various therapeutic areas.
• Protease Inhibitor Research: Used in the design and construction of inhibitors for enzymes like proteases, where the pyrimidine moiety can act as a key pharmacophore.
• Chemical Biology Probes: Serves as a building block for creating labeled peptides or activity-based probes to study biological pathways and protein function.
• Peptidomimetic Development: Essential for creating non-natural peptide analogs with enhanced stability, bioavailability, and target specificity.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse compound libraries for high-throughput screening in drug discovery programs.
• Academic & Contract Research: Used in university laboratories and CROs (Contract Research Organizations) for fundamental research and custom synthesis projects.

Basic Information

Product Name	2-{[(tert-Butoxy)Carbonyl]Amino}-3-(Pyrimidin-2-Yl)Propanoic Acid
CAS No.	1404878-37-0
Molecular Formula	C12H17N3O4
Molecular Weight	267.28 g/mol
Synonyms	Boc-3-(2-Pyrimidyl)-L-alanine; N-Boc-3-(2-pyrimidyl)-L-alanine; (S)-2-((tert-Butoxycarbonyl)amino)-3-(pyrimidin-2-yl)propanoic acid; 2-[(tert-Butoxycarbonyl)amino]-3-(2-pyrimidinyl)propanoic acid; Boc-L-3-(2-Pyrimidyl)alanine; N-(tert-Butoxycarbonyl)-3-(2-pyrimidinyl)-L-alanine; 1404878-37-0; 2-[[(2-Methylpropan-2-yl)oxycarbonyl]amino]-3-pyrimidin-2-ylpropanoic acid
EINECS	Contact for details

Quality Control

Our 2-{[(tert-Butoxy)Carbonyl]Amino}-3-(Pyrimidin-2-Yl)Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, NMR, and MS for structural confirmation, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.