Description

6-Chloro-1-(4-Methoxyphenyl)-1H-Pyrazolo[3,4-D]Pyrimidine is a high-purity, advanced pharmaceutical intermediate belonging to the pyrazolopyrimidine class of heterocyclic compounds. This compound is of significant commercial interest for its role as a key building block in the synthesis of targeted therapeutic agents, particularly kinase inhibitors. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of novel small-molecule drugs for oncology and inflammatory diseases.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potent and selective kinase inhibitors.
• Oncology Drug Discovery: Used in research and development of targeted cancer therapies that modulate specific signaling pathways.
• Biochemical Research: Employed as a reference standard or a tool compound in enzymatic assays and biological activity studies.
• Custom Synthesis: A starting material for the preparation of more complex, functionalized pyrazolopyrimidine derivatives for structure-activity relationship (SAR) studies.
• API Manufacturing: Integrated into the commercial-scale production of active pharmaceutical ingredients (APIs) for clinical and commercial use.

Basic Information

Product Name	6-Chloro-1-(4-Methoxyphenyl)-1H-Pyrazolo[3,4-D]Pyrimidine
CAS No.	1404437-70-2
Molecular Formula	C₁₂H₉ClN₄O
Molecular Weight	260.68 g/mol
Synonyms	6-Chloro-1-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine; 1-(4-Methoxyphenyl)-6-chloro-1H-pyrazolo[3,4-d]pyrimidine; 6-Chloro-1-(p-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine; 1404437-70-2; Pyrazolo[3,4-d]pyrimidine, 6-chloro-1-(4-methoxyphenyl)-; 6-Chloro-1-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine; 1H-Pyrazolo[3,4-d]pyrimidine, 6-chloro-1-(4-methoxyphenyl)-
EINECS	Contact for details

Quality Control

Our 6-Chloro-1-(4-Methoxyphenyl)-1H-Pyrazolo[3,4-D]Pyrimidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced analytical techniques. We support development and commercial projects requiring material that meets stringent internal specifications aligned with ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound should be kept under an inert atmosphere for long-term storage to ensure stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.