Description

2-Chloro-5H,6H,7H-Pyrrolo[2,3-D]Pyrimidin-6-One Hydrochloride is a high-purity pharmaceutical intermediate and building block of significant importance in modern organic synthesis. This compound matters for its role as a key precursor in the development of novel therapeutic agents, particularly within kinase inhibitor research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of targeted kinase inhibitors and other small-molecule drug candidates.
• Biochemical Research: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Chemical Synthesis: Serves as a versatile precursor for further functionalization to create libraries of pyrrolopyrimidine derivatives.
• API Development: Employed in the research and process development stages of Active Pharmaceutical Ingredient (API) manufacturing.
• Academic Research: Utilized in university and institutional labs for exploring new synthetic methodologies and biological pathways.

Basic Information

Product Name	2-Chloro-5H,6H,7H-Pyrrolo[2,3-D]Pyrimidin-6-One Hydrochloride
CAS No.	1404373-76-7
Molecular Formula	C6H5ClN3O·HCl
Molecular Weight	208.04 g/mol (Free base: 170.57 g/mol)
Synonyms	2-Chloro-5,6,7,8-tetrahydropyrrolo[2,3-d]pyrimidin-6-one hydrochloride; 2-Chloro-6-oxo-5,6,7,8-tetrahydropyrrolo[2,3-d]pyrimidine hydrochloride; 6H-Pyrrolo[2,3-d]pyrimidin-6-one, 2-chloro-5,7-dihydro-, hydrochloride; 2-Chloro-7,8-dihydro-5H-pyrrolo[2,3-d]pyrimidin-6-one HCl; 2-Chloro-5H-pyrrolo[2,3-d]pyrimidin-6(7H)-one hydrochloride
EINECS	Contact for details

Quality Control

Our 2-Chloro-5H,6H,7H-Pyrrolo[2,3-D]Pyrimidin-6-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with exacting standards for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are available for every lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.