Description

4-Chloro-8-Fluoro-2-Methyl-Quinazoline is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters because its unique halogenated quinazoline structure serves as a critical precursor for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to introduce complex molecular modifications.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of kinase inhibitors, anticancer agents, and other biologically active quinazoline derivatives.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides, leveraging its halogen-substituted quinazoline core.
• Material Science: Serves as a building block for creating organic electronic materials, ligands for catalysis, and specialty polymers.
• Chemical Synthesis: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitution reactions to create diverse chemical libraries.
• Academic & Contract Research: Employed in universities and CROs for medicinal chemistry programs and structure-activity relationship (SAR) studies.

Basic Information

Product Name	4-Chloro-8-Fluoro-2-Methyl-Quinazoline
CAS No.	1404365-01-0
Molecular Formula	C9H6ClFN2
Molecular Weight	196.61 g/mol
Synonyms	4-Chloro-8-fluoro-2-methylquinazoline; 2-Methyl-4-chloro-8-fluoroquinazoline; Quinazoline, 4-chloro-8-fluoro-2-methyl-; 8-Fluoro-4-chloro-2-methylquinazoline; 1404365-01-0
EINECS	Contact for details

Quality Control

Our 4-Chloro-8-Fluoro-2-Methyl-Quinazoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.