Description

2-Bromo-3,6-Difluorobenzyl Alcohol is a versatile fluorinated benzyl alcohol derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of bromine and fluorine atoms, which enable selective functionalization and modulate the electronic properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), especially in fluorine-containing drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the difluorobenzyl moiety enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic cores in electronic materials, improving charge transport and thermal stability.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Ligand & Catalyst Development: Utilized in synthesizing specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Research: A valuable reagent for studying structure-activity relationships (SAR) and introducing fluorine atoms into molecular scaffolds.

Basic Information

Product Name	2-Bromo-3,6-Difluorobenzyl Alcohol
CAS No.	1404115-38-3
Molecular Formula	C7H5BrF2O
Molecular Weight	223.02 g/mol
Synonyms	(2-Bromo-3,6-difluorophenyl)methanol; 2-Bromo-3,6-difluorobenzyl alcohol; α-Bromo-3,6-difluorobenzyl alcohol; (2-Bromo-3,6-difluorophenyl)carbinol; Benzyl alcohol, 2-bromo-3,6-difluoro-; 3,6-Difluoro-2-bromobenzyl alcohol; 1404115-38-3
EINECS	Contact for details

Quality Control

Our 2-Bromo-3,6-Difluorobenzyl Alcohol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be amber glass or opaque. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.