Description

Fmoc-α-Me-D-Asn-Oh is a high-purity, non-natural amino acid derivative specifically engineered for advanced peptide synthesis. This compound is a critical building block for the development of novel peptide-based pharmaceuticals and research tools, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, particularly for creating peptides with enhanced metabolic stability and bioavailability. Its reliable quality makes it an essential reagent for chemists developing next-generation therapeutic candidates.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the sequential construction of complex peptide chains, especially in Fmoc-based strategies.
• Pharmaceutical Research & Development: Serves as a crucial intermediate in the synthesis of peptide drug candidates, including those for oncology, metabolic diseases, and neurology.
• Peptidomimetic Design: Used to incorporate α-methylated asparagine analogs into peptide backbones to enhance resistance to enzymatic degradation and improve pharmacological properties.
• Bioconjugation and Probe Development: Acts as a starting material for creating labeled peptides or peptide-conjugates used in diagnostic assays and biochemical studies.
• Academic Research: Employed in university and institutional labs for studying protein-protein interactions, enzyme specificity, and structure-activity relationships (SAR).
• Custom Peptide Service Providers: A fundamental raw material for CROs and CDMOs offering bespoke peptide synthesis services to the biotech industry.

Basic Information

Product Name	Fmoc-α-Me-D-Asn-Oh
CAS No.	1403590-50-0
Molecular Formula	C₂₀H₂₀N₂O₅
Molecular Weight	368.38 g/mol
Synonyms	Fmoc-α-methyl-D-asparagine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-α-methyl-D-asparagine; Fmoc-D-α-Me-Asn-OH; Fmoc-D-α-methylasparagine; (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-2-methyl-3-carbamoylpropanoic acid; Fmoc-α-Me-D-Asn-OH; N-Fmoc-α-methyl-D-asparagine; Fmoc-D-Asn(α-Me)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-α-Me-D-Asn-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and NMR for structural confirmation. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with the stringent requirements of pharmaceutical R&D and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.