Description

2-(Chloromethyl)-4-Cyclopropylpyrimidine is a high-value pyrimidine derivative featuring a reactive chloromethyl group and a cyclopropyl substituent, making it a versatile and critical building block in advanced organic synthesis. Its primary value lies in its role as a key intermediate for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce the 4-cyclopropylpyrimidine scaffold into target molecules.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, antiviral agents, and kinase inhibitors.
• Agrochemical Synthesis: Serves as a key building block for developing new-generation herbicides, fungicides, and insecticides with the cyclopropylpyrimidine moiety.
• Chemical Research & Development: Used in medicinal chemistry and process chemistry for structure-activity relationship (SAR) studies and route scouting.
• Ligand & Catalyst Preparation: Employed in the synthesis of specialized ligands for metal-catalyzed cross-coupling reactions and other catalytic processes.
• Material Science Precursor: Potential intermediate for creating functionalized organic materials and polymers with specific electronic properties.

Basic Information

Product Name	2-(Chloromethyl)-4-Cyclopropylpyrimidine
CAS No.	1402149-14-7
Molecular Formula	C8H9ClN2
Molecular Weight	168.62 g/mol
Synonyms	4-Cyclopropyl-2-(chloromethyl)pyrimidine; 2-(Chloromethyl)-4-cyclopropyl-pyrimidine; 4-Cyclopropyl-2-pyrimidinylmethyl chloride; Pyrimidine, 2-(chloromethyl)-4-cyclopropyl-; 1402149-14-7
EINECS	Contact for details

Quality Control

Our 2-(Chloromethyl)-4-Cyclopropylpyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures the material meets the high standards required for pharmaceutical and agrochemical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flames. Due to the reactive chloromethyl group, it should be stored separately from strong bases and nucleophiles.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC/GC-MS)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.