Description

tert-Butyl 2,4-Dichloro-5H-Pyrrolo[3,2-D]Pyrimidine-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the pyrrolopyrimidine class of heterocyclic compounds. This compound serves as a critical building block in modern medicinal chemistry, enabling the synthesis of targeted therapeutic agents. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel kinase inhibitors for oncology and inflammatory diseases.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in the multi-step synthesis of complex active pharmaceutical ingredients (APIs) targeting specific biological pathways.
• Biochemical Tool Compound: Serves as a starting material for creating labeled probes or tool compounds used in biochemical and cellular assays.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP-compliant production of clinical trial materials.

Basic Information

Product Name	tert-Butyl 2,4-Dichloro-5H-Pyrrolo[3,2-D]Pyrimidine-5-Carboxylate
CAS No.	1402148-73-5
Molecular Formula	C11H11Cl2N3O2
Molecular Weight	288.13 g/mol
Synonyms	5H-Pyrrolo[3,2-d]pyrimidine-5-carboxylic acid, 2,4-dichloro-, 1,1-dimethylethyl ester; 2,4-Dichloro-5-((tert-butoxy)carbonyl)-5H-pyrrolo[3,2-d]pyrimidine; tert-Butyl 2,4-dichloro-5H-pyrrolo[3,2-d]pyrimidine-5-carboxylate; 1402148-73-5; BOC-protected 2,4-dichloropyrrolopyrimidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 2,4-Dichloro-5H-Pyrrolo[3,2-D]Pyrimidine-5-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided for every shipment. We support development from research to commercial scale with material produced under appropriate GMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.