Description

n-Fmoc-o-Phenyl-L-Serine CAS NO 1401662-77-8 is a protected, non-proteinogenic amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound is critical for introducing the unique o-phenylserine moiety into peptide chains, enabling the creation of complex biomolecules with tailored properties. It is an essential building block for researchers and manufacturers in pharmaceutical development, particularly for creating peptide-based therapeutics, diagnostic agents, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptides containing o-phenylserine residues.
• Pharmaceutical Intermediate: Used in the research and development of novel peptide drugs, including antimicrobial peptides and hormone analogs.
• Bioconjugation: Serves as a specialized linker or handle for attaching peptides to other molecules, surfaces, or fluorophores in bioconjugation chemistry.
• Chemical Biology Research: Employed in the study of protein-protein interactions and the development of enzyme inhibitors or receptor modulators.
• Combinatorial Library Synthesis: A valuable component for generating diverse peptide libraries for high-throughput screening in drug discovery.
• Glycopeptide Mimetics: Used in the synthesis of peptide mimics that replicate the structure and function of natural glycopeptides.

Basic Information

Product Name	n-Fmoc-o-Phenyl-L-Serine
CAS No.	1401662-77-8
Molecular Formula	C24H21NO5
Molecular Weight	403.43 g/mol
Synonyms	Fmoc-o-Phenylserine-OH; Fmoc-L-o-Phenylserine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-o-phenyl-L-serine; (2S)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(2-hydroxyphenyl)acetic acid; Fmoc-Ser(Ph)-OH; o-Phenyl-L-serine, N-Fmoc derivative; Fmoc-O-phenyl-L-serine; N-α-Fmoc-o-phenyl-L-serine
EINECS	Contact for details

Quality Control

Our n-Fmoc-o-Phenyl-L-Serine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. We support cGMP-compliant production for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.