Description

ε-n-Crotonyllysine is a modified amino acid derivative characterized by a specific crotonyl group attached to the ε-amino group of lysine. This compound is of significant interest in biochemical and pharmaceutical research, particularly in the study of post-translational modifications, epigenetics, and metabolic pathways. It serves as a critical reference standard, building block, or active pharmaceutical ingredient (API) intermediate for researchers and manufacturers in the life sciences sector. Key industries requiring this high-purity specialty chemical include pharmaceutical development, biotechnology, and advanced academic research.

Application

• Biochemical Research Standard: Used as a high-purity reference standard in mass spectrometry and analytical studies of protein lysine crotonylation, a key epigenetic marker.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel drug candidates targeting epigenetic regulation and metabolic diseases.
• Enzyme Substrate & Inhibitor Studies: Employed in enzymatic assays to study the activity of deacetylases (like sirtuins) and other enzymes involved in acyl-lysine recognition.
• Proteomics & Biomarker Discovery: Utilized in the development and calibration of methods for the detection and quantification of crotonylated proteins in complex biological samples.
• Cell Culture & Metabolic Pathway Analysis: Applied in cell-based studies to investigate the role of lysine crotonylation in cellular signaling, metabolism, and disease states.
• Antibody & Assay Development: Acts as a hapten for generating specific antibodies against crotonyl-lysine motifs for use in Western blotting, immunohistochemistry, and ELISA.

Basic Information

Product Name	ε-n-Crotonyllysine
CAS No.	1399861-03-0
Molecular Formula	C10H18N2O3
Molecular Weight	214.26 g/mol
Synonyms	N6-Crotonyl-L-lysine; L-Lysine, N6-(2-butenoyl)-; ε-N-Crotonyl-L-lysine; Crotonyl-lysine; Kcr; (2S)-6-[(2E)-But-2-enoylamino]-2-aminohexanoic acid; N-ε-Crotonyllysine; Crotonylated Lysine
EINECS	Contact for details

Quality Control

Our ε-n-Crotonyllysine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.