Description

2-(1H-Pyrazol-1-yl)-5-(trifluoromethyl)pyrimidine is a high-value, heterocyclic building block featuring a pyrimidine core substituted with a pyrazole ring and a trifluoromethyl group. This molecular architecture is critical for imparting enhanced metabolic stability, lipophilicity, and binding affinity in advanced chemical synthesis. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, particularly in medicinal chemistry for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the design and production of advanced crop protection agents, leveraging the bioactivity of the pyrimidine-pyrazole scaffold.
• Chemical Biology Probe Development: Serves as a core structure for creating molecular probes to study biological pathways and protein functions.
• Material Science Research: Investigated as a precursor for specialty chemicals and functional materials due to its unique electronic properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	2-(1H-Pyrazol-1-yl)-5-(trifluoromethyl)pyrimidine
CAS No.	1398504-38-5
Molecular Formula	C8H5F3N4
Molecular Weight	214.15 g/mol
Synonyms	5-(Trifluoromethyl)-2-(1H-pyrazol-1-yl)pyrimidine; 2-(1H-Pyrazol-1-yl)-5-(trifluoromethyl)pyrimidine; 2-(Pyrazol-1-yl)-5-trifluoromethylpyrimidine; 1-(5-Trifluoromethylpyrimidin-2-yl)-1H-pyrazole; Pyrimidine, 2-(1H-pyrazol-1-yl)-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 2-(1H-Pyrazol-1-yl)-5-(trifluoromethyl)pyrimidine is manufactured under a strict quality management system. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed HPLC/GC purity data, to ensure the material meets your precise research and development specifications. Our quality commitment ensures batch-to-batch consistency and traceability for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong alkalis and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.