Description

tert-Butyl 2-(tert-Butyl)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate CAS NO 1395493-24-9 is a high-purity, advanced pharmaceutical intermediate featuring a complex dihydropyridopyrimidine core. This compound is of significant value for its role as a key building block in the synthesis of novel, small-molecule therapeutic agents. It is primarily sought after by research institutions and pharmaceutical companies engaged in drug discovery and development, particularly within oncology and other disease areas targeting kinase pathways.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of investigational drug candidates, especially kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to develop new chemical entities.
• Chemical Biology Probes: Serves as a scaffold for creating tool compounds to study specific biological targets and pathways.
• Contract Development and Manufacturing (CDMO): Supplied to CDMOs for scale-up synthesis under cGMP conditions for clinical trial material production.
• Academic Research: Utilized in university and institutional labs for fundamental research in heterocyclic chemistry and drug design.

Basic Information

Product Name	tert-Butyl 2-(tert-Butyl)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
CAS No.	1395493-24-9
Molecular Formula	C16H25N3O2
Molecular Weight	291.39 g/mol
Synonyms	7-tert-Butoxycarbonyl-2-tert-butyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine; 2-tert-Butyl-7-(tert-butoxycarbonyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine; 5,6,7,8-Tetrahydropyrido[3,4-d]pyrimidine-7-carboxylic acid, 2-(1,1-dimethylethyl)-, 1,1-dimethylethyl ester; tert-Butyl 2-tert-butyl-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylate; BOC-protected dihydropyridopyrimidine intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for pharmaceutical R&D. Each batch undergoes comprehensive analytical characterization, including HPLC for purity and identity confirmation via NMR and MS. We provide detailed Certificates of Analysis (COA) with each shipment, ensuring traceability and compliance with your internal quality standards. Specifications can be aligned with current Good Manufacturing Practice (cGMP) principles for development purposes upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.