Description

2-Cyclopropyl-5,8-Dihydro-6H-Pyrido[3,4-D]Pyrimidine-7-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate crucial for modern drug discovery and development. This compound serves as a key building block in the synthesis of complex, biologically active molecules, particularly in the field of kinase inhibitors. It is essential for research institutions and pharmaceutical manufacturers engaged in developing new therapeutic agents for oncology and other disease areas. The consistent quality and reliable supply of this intermediate directly impact the efficiency and success of downstream API synthesis.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel kinase inhibitor drug candidates.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities.
• Process Chemistry Development: Serves as a key starting material (KSM) or intermediate in scaling up API manufacturing processes under GMP conditions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.
• Biochemical Tool Compound Synthesis: Used to create specialized probes for studying specific biological pathways and target validation.

Basic Information

Product Name	2-Cyclopropyl-5,8-Dihydro-6H-Pyrido[3,4-D]Pyrimidine-7-Carboxylic Acid tert-Butyl Ester
CAS No.	1395493-05-6
Molecular Formula	C15H19N3O2
Molecular Weight	273.33 g/mol
Synonyms	tert-Butyl 2-cyclopropyl-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylate; 6H-Pyrido[3,4-d]pyrimidine-7-carboxylic acid, 2-cyclopropyl-5,8-dihydro-, 1,1-dimethylethyl ester; 2-Cyclopropyl-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid 1,1-dimethylethyl ester; 2-Cyclopropyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-7-carboxylic acid tert-butyl ester; CAS 1395493-05-6
EINECS	Contact for details

Quality Control

Our 2-Cyclopropyl-5,8-Dihydro-6H-Pyrido[3,4-D]Pyrimidine-7-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet client-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.