Description

2-(4-Fluorophenyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylic acid is a high-purity, advanced pharmaceutical intermediate with a complex fused heterocyclic structure. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel, targeted therapeutic agents. It is primarily required by R&D organizations and manufacturers in the pharmaceutical and biotechnology sectors engaged in developing kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates, particularly in oncology and inflammatory disease research.
• Kinase Inhibitor Development: Serves as a core scaffold for designing and synthesizing novel protein kinase inhibitors due to its dihydropyridopyrimidine structure.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes in drug discovery pipelines.
• Biochemical Tool Compound: May be utilized in biochemical assays to study enzyme function and cellular signaling pathways.
• Custom Synthesis Building Block: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke chemical synthesis projects.

Basic Information

Product Name	2-(4-Fluorophenyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylic acid
CAS No.	1395492-92-8
Molecular Formula	C₁₅H₁₂FN₃O₂
Molecular Weight	285.27 g/mol
Synonyms	2-(4-Fluorophenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-6-carboxylic acid; 6-Carboxy-2-(4-fluorophenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine; 1395492-92-8; 2-(p-Fluorophenyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylic acid; Fluorophenyl dihydropyridopyrimidine carboxylic acid
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for pharmaceutical R&D. Each batch is characterized and tested to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as HPLC purity, NMR confirmation, and residual solvent levels are provided with every shipment. We support compliance with ICH guidelines and can tailor quality controls to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.