Description

Fmoc-Val-Ala-Pab-Pnp CAS NO 1394238-92-6 is a specialized, high-purity protected peptide building block designed for solid-phase peptide synthesis (SPPS). This compound is critical for the efficient and controlled construction of complex peptide sequences, particularly in the development of novel therapeutic agents and research tools. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and academic research institutions focused on peptide-based drug discovery and biochemical studies.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid derivative for the sequential assembly of custom peptide chains.
• Pharmaceutical Research: For the synthesis of peptide drug candidates, including protease inhibitors and targeted therapeutics.
• Bioconjugation: Serving as an intermediate for attaching peptides to other molecules, surfaces, or carriers via its reactive Pnp (p-nitrophenyl ester) group.
• Chemical Biology Probes: Used in the creation of labeled or modified peptides for studying protein-protein interactions and enzyme activity.
• Antibody-Drug Conjugate (ADC) Development: As a component in the synthesis of peptide linkers for connecting cytotoxic payloads to antibodies.
• Combinatorial Chemistry: A valuable building block in libraries for high-throughput screening of bioactive peptides.

Basic Information

Product Name	Fmoc-Val-Ala-Pab-Pnp
CAS No.	1394238-92-6
Molecular Formula	C₃₆H₄₁N₅O₉
Molecular Weight	687.75 g/mol
Synonyms	Fmoc-Val-Ala-PAB(OMe)-OPnp; Fmoc-Val-Ala-Pab(OMe)-OPnp; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valyl-N-[(1S)-1-[[(4-methoxyphenyl)amino]methyl]-2-(4-nitrophenoxy)-2-oxoethyl]-L-alaninamide; Fmoc-L-Val-L-Ala-Pab(OMe)-OPnp; Fmoc-Val-Ala-PAB(OMe)-p-nitrophenyl ester; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-methylbutanoyl-L-alanyl-N-((S)-1-((4-methoxyphenyl)amino)-1-oxo-3-(4-nitrophenoxy)propan-2-yl)carboxamide
EINECS	Contact for details

Quality Control

Our Fmoc-Val-Ala-Pab-Pnp is manufactured under strict quality control protocols to ensure the high purity and consistency required for sensitive synthetic applications. Each batch is analyzed using advanced chromatographic techniques, including HPLC and LC-MS, to verify identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert atmosphere. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Single Impurity (HPLC)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.