Description

4-Chloro-5-Ethynylpyrimidin-2-Amine is a high-purity, functionalized pyrimidine building block of significant interest in advanced organic synthesis. This compound matters as a versatile intermediate, offering a unique combination of a reactive chloro substituent and an ethynyl group for further derivatization via cross-coupling and click chemistry. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and plant growth regulators.
• Chemical Biology & Proteomics: Serves as a handle for bioconjugation and labeling via its alkyne functionality for click chemistry applications.
• Material Science: A potential monomer or cross-linker in the synthesis of specialized polymers and functional materials.
• Academic & Contract Research: Employed in methodological studies and as a building block for library synthesis in drug discovery programs.

Basic Information

Product Name	4-Chloro-5-Ethynylpyrimidin-2-Amine
CAS No.	1392804-24-8
Molecular Formula	C6H4ClN3
Molecular Weight	153.57 g/mol
Synonyms	2-Amino-4-chloro-5-ethynylpyrimidine; 5-Ethynyl-4-chloropyrimidin-2-amine; 4-Chloro-5-ethynyl-2-pyrimidinamine; 1392804-24-8
EINECS	Contact for details

Quality Control

Our 4-Chloro-5-Ethynylpyrimidin-2-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided to guarantee batch-to-batch consistency and support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere for long-term storage to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.