Description

5-Bromo-7-[trans-4-(tert-butyldimethylsilanyloxy)cyclohexyl]-2-chloro-7H-pyrrolo[2,3-d]pyrimidine is a high-purity, advanced pharmaceutical intermediate designed for complex synthesis pathways. This compound is critical for medicinal chemistry research and development, particularly in the construction of kinase inhibitor scaffolds. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries seeking to develop novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of targeted small molecule drugs, especially kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs.
• Process Chemistry Development: Serves as a critical starting material for scaling up synthetic routes to active pharmaceutical ingredients (APIs).
• Chemical Biology Probes: Utilized in the development of chemical probes for studying specific biological pathways and target validation.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific projects requiring complex heterocyclic chemistry.

Basic Information

Product Name	5-Bromo-7-[trans-4-(tert-butyldimethylsilanyloxy)cyclohexyl]-2-chloro-7H-pyrrolo[2,3-d]pyrimidine
CAS No.	1392804-15-7
Molecular Formula	C18H27BrClN3OSi
Molecular Weight	444.87 g/mol
Synonyms	5-Bromo-7-[trans-4-[(tert-butyldimethylsilyl)oxy]cyclohexyl]-2-chloro-7H-pyrrolo[2,3-d]pyrimidine; 2-Chloro-5-bromo-7-[trans-4-(tert-butyldimethylsiloxy)cyclohexyl]-7H-pyrrolo[2,3-d]pyrimidine; 5-Bromo-2-chloro-7-(trans-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidine; 1392804-15-7; TBDMS-protected pyrrolopyrimidine intermediate; CAS 1392804-15-7
EINECS	Contact for details

Quality Control

Our 5-Bromo-7-[trans-4-(tert-butyldimethylsilanyloxy)cyclohexyl]-2-chloro-7H-pyrrolo[2,3-d]pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.