Description

5,5-Difluoro-6,8-Dihydro-5H-Pyrano[3,4-D]Pyrimidin-2-Amine (Wx141263) is a high-purity, advanced pharmaceutical intermediate featuring a unique fused pyrano-pyrimidine scaffold. This compound matters as a critical building block for medicinal chemistry research and development, enabling the synthesis of novel drug candidates with potential therapeutic applications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and agrochemical industries for creating innovative small-molecule libraries and active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in oncology, antiviral, and CNS therapeutic areas.
• Medicinal Chemistry Research: Used as a core scaffold or precursor in structure-activity relationship (SAR) studies and hit-to-lead optimization programs.
• Agrochemical Development: Serves as a building block for novel herbicides, fungicides, or insecticides, leveraging its heterocyclic structure.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up services.
• Academic Research: Employed in university and institutional labs for fundamental research in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	5,5-Difluoro-6,8-Dihydro-5H-Pyrano[3,4-D]Pyrimidin-2-Amine (Wx141263)
CAS No.	1391733-01-9
Molecular Formula	C7H7F2N3O
Molecular Weight	187.15 g/mol
Synonyms	2-Amino-5,5-difluoro-5,6-dihydro-8H-pyrano[3,4-d]pyrimidine; 5,5-Difluoro-6,8-dihydro-5H-pyrano[3,4-d]pyrimidin-2-amine; WX-141263; Wx141263; 1391733-01-9; 5H-Pyrano[3,4-d]pyrimidin-2-amine, 5,5-difluoro-6,8-dihydro-; Pyrano[3,4-d]pyrimidine derivative
EINECS	Contact for details

Quality Control

Our 5,5-Difluoro-6,8-Dihydro-5H-Pyrano[3,4-D]Pyrimidin-2-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for your critical R&D and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.