Description

(9H-Fluoren-9-Yl)Methoxy]Carbonyl D-2-Iodotyrosine is a specialized, non-natural amino acid derivative designed for advanced peptide synthesis and pharmaceutical research. This compound is critical for introducing the unique D-2-iodotyrosine moiety into peptide chains under Fmoc-based solid-phase synthesis protocols. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on developing novel peptide-based therapeutics, diagnostic agents, and biochemical probes.

Application

• Fmoc-SPPS (Solid-Phase Peptide Synthesis): As a key building block for the controlled incorporation of iodinated tyrosine residues into custom peptide sequences.
• Pharmaceutical Intermediate: For the research and development of peptide drugs, including potential hormone analogs and receptor-targeting agents.
• Radiolabeling Precursor: Serves as a precursor molecule for the synthesis of compounds intended for radiolabeling with iodine-125 or iodine-131 for diagnostic imaging or therapeutic applications.
• Bioconjugation & Probe Development: Used to create peptide-based probes for studying protein-protein interactions, enzyme activity, and cellular localization.
• Chemical Biology Research: Enables the study of tyrosine function and iodine's role in biological systems through site-specific modification of synthetic peptides.
• Reference Standard: Acts as a high-purity analytical standard for quality control in peptide manufacturing and related research.

Basic Information

Product Name	(9H-Fluoren-9-Yl)Methoxy]Carbonyl D-2-Iodotyrosine
CAS No.	1391567-02-4
Molecular Formula	C24H18INO5
Molecular Weight	527.31 g/mol
Synonyms	Fmoc-D-2-Iodotyrosine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-iodo-D-tyrosine; Fmoc-D-Tyr(2I)-OH; Fmoc-3-iodo-D-tyrosine; N-Fmoc-3-iodo-D-tyrosine; D-2-Iodotyrosine Fmoc derivative; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-(3-iodo-4-hydroxyphenyl)propanoic acid
EINECS	Contact for details

Quality Control

Our (9H-Fluoren-9-Yl)Methoxy]Carbonyl D-2-Iodotyrosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm the D-configuration, and identity confirmation via NMR and mass spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports applications requiring high levels of consistency and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.