Description

L-3-Phenyl-Phenylalanine Hcl is a non-natural, phenylalanine-derived amino acid analog featuring an additional phenyl substituent. This structural modification makes it a valuable chiral building block and intermediate for advanced pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the synthesis of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs) where enhanced lipophilicity and specific steric interactions are required.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic peptides and small molecule drugs.
• Peptidomimetic Design: Used to incorporate modified phenylalanine residues into peptide backbones to improve metabolic stability, bioavailability, and receptor binding affinity.
• Protease Inhibitor Development: Serves as a core structural component in the design of inhibitors for various enzyme targets.
• Chemical Biology Research: Employed as a tool compound for studying protein-protein interactions and enzyme mechanisms.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in stereoselective synthetic routes.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	L-3-Phenyl-Phenylalanine Hcl
CAS No.	1391513-53-3
Molecular Formula	C15H16ClNO2
Molecular Weight	277.75 g/mol
Synonyms	L-3-Phenylphenylalanine hydrochloride; (S)-2-Amino-3-(1,1'-biphenyl-3-yl)propanoic acid hydrochloride; 3-Phenyl-L-phenylalanine HCl; 3-Biphenyl-L-alanine hydrochloride; H-3-Pal(3-Ph)-OH·HCl; Biphenylalanine hydrochloride; (S)-3-(3-Phenylphenyl)alanine hydrochloride
EINECS	Contact for details

Quality Control

Our L-3-Phenyl-Phenylalanine Hcl is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) providing specifications for identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.