Description

(R)-2,2,2-Trifluoro-1-p-Tolyl-Ethylamine Hydrochloride is a high-purity chiral amine building block, specifically the hydrochloride salt of the (R)-enantiomer. This compound is a critical intermediate in the synthesis of advanced pharmaceutical agents, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas requiring enantiomerically pure molecules. It is essential for medicinal chemistry research, process development, and scale-up manufacturing within the pharmaceutical and biotechnology industries.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), especially in CNS drug candidates.
• Asymmetric Synthesis: Used as a chiral auxiliary or resolving agent in stereoselective chemical reactions to introduce trifluoromethyl and aromatic functionalities.
• Medicinal Chemistry R&D: Serves as a versatile building block for constructing compound libraries in drug discovery programs focused on potency and metabolic stability.
• Process Chemistry: Employed in the optimization and commercial-scale production routes for enantiomerically pure drugs.
• Agrochemical Research: Potential intermediate in the synthesis of advanced, optically active crop protection agents.
• Material Science: Investigated for incorporation into specialty polymers or liquid crystals where chiral and fluorinated properties are desired.

Basic Information

Item	Details
Product Name	(R)-2,2,2-Trifluoro-1-p-Tolyl-Ethylamine Hydrochloride
CAS No.	1391458-37-9
Molecular Formula	C9H11F3N·HCl
Molecular Weight	229.65 g/mol
Synonyms	(R)-1-(4-Methylphenyl)-2,2,2-trifluoroethylamine hydrochloride; (R)-α-(Trifluoromethyl)-4-methylbenzeneethanamine hydrochloride; (R)-2,2,2-Trifluoro-1-(4-methylphenyl)ethanamine hydrochloride; (R)-1-(p-Tolyl)-2,2,2-trifluoroethylamine HCl; (R)-p-Methyl-α-(trifluoromethyl)benzylamine hydrochloride; (R)-TFE-amine HCl; (R)-CF3-PEA HCl
EINECS	Contact for details

Quality Control

Our (R)-2,2,2-Trifluoro-1-p-Tolyl-Ethylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP intermediate applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.