Description

(Alphas)-3-Fluoro-α-(Trifluoromethyl)Benzenemethanamine Hydrochloride (1:1) is a high-purity, fluorinated chiral amine building block, essential for advanced pharmaceutical and agrochemical synthesis. Its core value lies in introducing a unique trifluoromethylated benzylic amine motif, which is critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. This compound is primarily needed by R&D scientists and process chemists in the pharmaceutical industry for developing new active ingredients, particularly in CNS and oncology research.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs), especially in central nervous system (CNS) and oncology drug candidates.
• Agrochemical Research: Used in the development of advanced herbicides, fungicides, and insecticides where the fluorine and trifluoromethyl groups enhance biological activity and environmental stability.
• Ligand & Catalyst Synthesis: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis, enabling the production of enantiomerically pure compounds.
• Material Science: Potential monomer or additive for specialty polymers and advanced materials, leveraging its fluorine content to alter surface properties and chemical resistance.
• Chemical Biology & Proteomics: Useful as a molecular probe or tag in bioconjugation chemistry due to its reactive amine handle and fluorine NMR signature.

Basic Information

Item	Details
Product Name	(Alphas)-3-Fluoro-α-(Trifluoromethyl)Benzenemethanamine Hydrochloride (1:1)
CAS No.	1391436-37-5
Molecular Formula	C9H8ClF4N
Molecular Weight	241.61 g/mol
Synonyms	(αS)-3-Fluoro-α-(trifluoromethyl)benzenemethanamine hydrochloride; (S)-3-Fluoro-α-(trifluoromethyl)benzylamine hydrochloride; (S)-1-(3-Fluorophenyl)-2,2,2-trifluoroethanamine hydrochloride; (S)-α-(Trifluoromethyl)-3-fluorobenzylamine hydrochloride; (S)-3-Fluoro-α-(trifluoromethyl)phenylmethanamine hydrochloride; (S)-1-(3-Fluorophenyl)-2,2,2-trifluoroethylamine hydrochloride; (αS)-3-Fluoro-α-(trifluoromethyl)benzylamine HCl
EINECS	Contact for details

Quality Control

Our (Alphas)-3-Fluoro-α-(Trifluoromethyl)Benzenemethanamine Hydrochloride (1:1) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity, NMR, and LC-MS for identity confirmation, to ensure compliance with pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing purity, impurities, and chiral excess are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.