Description

(1R)-2-Methyl-1-[4-(Trifluoromethyl)Phenyl]Propylamine Hydrochloride is a high-purity chiral amine hydrochloride salt, a critical building block in advanced organic synthesis. Its value lies in its defined stereochemistry and the presence of the trifluoromethyl group, which is highly sought after for modulating the physicochemical properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of new active ingredients and fine chemicals where precise molecular architecture is required.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and metabolic disorder therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to create enantiomerically pure compounds.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials that require specific fluorinated aromatic components.
• Chemical Reference Standard: Provides a high-purity standard for analytical method development, quality control, and regulatory submissions in GMP environments.

Basic Information

Product Name	(1R)-2-Methyl-1-[4-(Trifluoromethyl)Phenyl]Propylamine Hydrochloride
CAS No.	1391423-72-5
Molecular Formula	C11H14F3N·HCl
Molecular Weight	253.69 g/mol
Synonyms	(1R)-1-[4-(Trifluoromethyl)phenyl]-2-methylpropylamine hydrochloride; (R)-1-(4-(Trifluoromethyl)phenyl)-2-methylpropan-1-amine hydrochloride; (R)-2-Methyl-1-[4-(trifluoromethyl)phenyl]propan-1-amine hydrochloride; (R)-α-Methyl-4-(trifluoromethyl)benzenepropanamine hydrochloride; (1R)-1-(4-Trifluoromethylphenyl)-2-methylpropylamine HCl; (R)-TFMPA HCl; Benzenepropanamine, α-methyl-4-(trifluoromethyl)-, (αR)-, hydrochloride
EINECS	Contact for details

Quality Control

Our (1R)-2-Methyl-1-[4-(Trifluoromethyl)Phenyl]Propylamine Hydrochloride is manufactured under strict quality management systems. Every batch is subjected to comprehensive analytical testing, including chiral HPLC for enantiomeric purity, to ensure it meets the stringent requirements for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.