Description

(R)-1-(4-Fluorophenyl)But-3-En-1-Amine Hydrochloride CAS NO 1391361-52-6 is a high-purity chiral amine hydrochloride salt, characterized by its fluorinated aromatic ring and terminal alkene functionality. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. It is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries who require enantiomerically pure intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and synthesis of potential new drug candidates, particularly in central nervous system (CNS) and metabolic disorder therapeutic areas.
• Agrochemical Synthesis: Used in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators where specific stereochemistry is crucial for bioactivity.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to induce high enantioselectivity in chemical reactions.
• Fine Chemical Manufacturing: Employed in the production of specialty chemicals, flavors, and fragrances that require precise stereochemical control.
• Academic and R&D Laboratories: A valuable reagent for methodological development in organic chemistry and for studying structure-activity relationships (SAR).

Basic Information

Product Name	(R)-1-(4-Fluorophenyl)But-3-En-1-Amine Hydrochloride
CAS No.	1391361-52-6
Molecular Formula	C10H13FN • HCl
Molecular Weight	201.68 g/mol (Free base: 165.22 g/mol)
Synonyms	(R)-1-(4-Fluorophenyl)-3-buten-1-amine hydrochloride; (R)-4-Fluoro-α-vinylbenzenemethanamine hydrochloride; (R)-1-Amino-1-(4-fluorophenyl)-3-butene hydrochloride; (R)-4-Fluorophenylvinylmethylamine hydrochloride; (R)-1-(p-Fluorophenyl)-3-buten-1-amine HCl; (R)-1-(4-Fluorophenyl)but-3-en-1-amine HCl; (R)-F-Phe-vinyl-amine HCl; (R)-4-Fluoro-β,γ-unsaturated phenethylamine hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-1-(4-Fluorophenyl)But-3-En-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and fine chemical synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.