Description

(1S)-1-[3-(Difluoromethyl)-2-Fluorophenyl]Ethylamine is a high-purity chiral amine building block of significant importance in advanced pharmaceutical synthesis. Its value lies in its role as a key intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research and production facilities in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop novel therapeutics and crop protection agents.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs), especially in central nervous system (CNS) and anti-infective drug candidates.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the difluoromethyl and fluorine substituents can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to create enantiomerically pure compounds.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals and fluorinated organic compounds.
• Academic and R&D: A valuable reagent for medicinal chemistry research, process chemistry development, and exploring new synthetic methodologies in university and corporate laboratories.

Basic Information

Product Name	(1S)-1-[3-(Difluoromethyl)-2-Fluorophenyl]Ethylamine
CAS No.	1389366-49-7
Molecular Formula	C9H10F3N
Molecular Weight	189.18 g/mol
Synonyms	(1S)-1-(3-(Difluoromethyl)-2-fluorophenyl)ethan-1-amine; (S)-1-(3-(Difluoromethyl)-2-fluorophenyl)ethylamine; (S)-α-Methyl-3-(difluoromethyl)-2-fluorobenzeneethanamine; 1389366-49-7; (S)-1-[3-(Difluoromethyl)-2-fluorophenyl]ethylamine; (S)-1-(3-(Difluoromethyl)-2-fluorophenyl)ethanamine
EINECS	Contact for details

Quality Control

Our production of (1S)-1-[3-(Difluoromethyl)-2-Fluorophenyl]Ethylamine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Every lot is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong acids and strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR / NMR)	Conforms to structure
Purity (HPLC / GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.