Description

(S)-2-(4-Chloro-6,7-Dihydro-5H-Cyclopenta[4,5]Thieno[2,3-D]Pyrimidin-5-Yl)Ethanol is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound matters for its role as a key building block in the development of targeted kinase inhibitors and other advanced active pharmaceutical ingredients (APIs). Pharmaceutical R&D teams and fine chemical manufacturers need this material for its precise stereochemistry, which is critical for ensuring the efficacy and safety of final drug candidates.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the synthesis of novel kinase inhibitors for oncology and inflammatory disease research.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural component in the preclinical and clinical development of new chemical entities.
• Process Chemistry & Scale-Up: Used in route scouting, optimization, and pilot-scale manufacturing for pharmaceutical projects.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global drug discovery pipelines.
• Reference Standard: Employed as an analytical standard for method development and quality control of related compounds.
• Academic & Institutional Research: Utilized in medicinal chemistry programs for structure-activity relationship (SAR) studies.

Basic Information

Product Name	(S)-2-(4-Chloro-6,7-Dihydro-5H-Cyclopenta[4,5]Thieno[2,3-D]Pyrimidin-5-Yl)Ethanol
CAS No.	1388893-94-4
Molecular Formula	C11H11ClN2OS
Molecular Weight	254.73 g/mol
Synonyms	(5S)-5-(2-Hydroxyethyl)-4-chloro-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidine; (S)-4-Chloro-5-(2-hydroxyethyl)-5,6,7,8-tetrahydro-cyclopenta[4,5]thieno[2,3-d]pyrimidine; (S)-5-(2-Hydroxyethyl)-4-chloro-5,6,7,8-tetrahydrocyclopenta[4,5]thieno[2,3-d]pyrimidine; (S)-CCT129202 alcohol intermediate; (S)-Enantiomer of CCT129202 precursor; 1388893-94-4; (S)-form of the cyclopentathienopyrimidine ethanol derivative.
EINECS	Contact for details

Quality Control

Our (S)-2-(4-Chloro-6,7-Dihydro-5H-Cyclopenta[4,5]Thieno[2,3-D]Pyrimidin-5-Yl)Ethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.