Description

3-Bromo-2-Chloro-L-Phenylalanine is a non-natural, halogenated derivative of the essential amino acid L-phenylalanine, serving as a critical chiral building block in advanced organic synthesis. This compound is valued for its unique steric and electronic properties, which enable the precise construction of complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and specialized agrochemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in oncology and neurology.
• Peptide Chemistry: Used to incorporate halogenated phenylalanine analogs into peptides to modulate their bioactivity, stability, and binding affinity.
• Agrochemical Synthesis: Serves as a precursor in the design of novel herbicides and plant growth regulators with enhanced specificity.
• Chemical Biology Probe: Employed in biochemical studies to investigate protein structure-function relationships and enzyme mechanisms.
• Material Science Research: A building block for specialty polymers and liquid crystals where halogen atoms influence material properties.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	3-Bromo-2-Chloro-L-Phenylalanine
CAS No.	1388081-08-0
Molecular Formula	C9H9BrClNO2
Molecular Weight	278.53 g/mol
Synonyms	(2S)-2-Amino-3-(3-bromo-2-chlorophenyl)propanoic acid; L-3-Bromo-2-chlorophenylalanine; 3-Br-2-Cl-L-Phe; 3-Bromo-2-chloro-L-α-aminohydrocinnamic acid; (S)-2-Amino-3-(3-bromo-2-chloro-phenyl)-propionic acid; BOC-L-3-Bromo-2-chloro-phenylalanine; Fmoc-3-Bromo-2-chloro-L-phenylalanine
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-2-Chloro-L-Phenylalanine is manufactured under a strict quality management system and undergoes comprehensive analytical testing. We provide full traceability and guarantee consistent high purity, typically ≥98% (HPLC). A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting identity (IR, NMR), purity (HPLC), chiral purity, and residual solvent levels.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.