Description

Fmoc-L-Har(Et)2-Oh CAS NO 1386327-04-3 is a protected amino acid derivative featuring an Fmoc (9-fluorenylmethoxycarbonyl) group and a diethyl-substituted arginine side chain. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled introduction of a modified arginine residue with enhanced lipophilicity and altered charge properties. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptide therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of complex peptides.
• Peptide Drug Discovery: For incorporating modified arginine analogs to improve peptide stability, membrane permeability, or receptor binding affinity.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled peptides or peptide-based imaging agents.
• Enzyme Substrate & Inhibitor Design: Used in the study of proteases and other enzymes that recognize arginine-containing sequences.
• Chemical Biology Research: For exploring protein-protein interactions and signal transduction pathways using synthetic peptide mimics.
• Material Science: Potential use in the synthesis of peptide-based biomaterials and surface coatings.

Basic Information

Product Name	Fmoc-L-Har(Et)2-Oh
CAS No.	1386327-04-3
Molecular Formula	C₂₇H₃₆N₄O₅
Molecular Weight	496.60 g/mol
Synonyms	Fmoc-NG,NG'-diethyl-L-homoarginine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-NG,NG'-diethyl-L-homoarginine; Fmoc-L-Homoarginine(NG,NG'-diethyl)-OH; Fmoc-L-NG,NG'-diethylhomoarginine; Fmoc-Diethyl-homoArg-OH; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-(diethylamino)hexanoic acid; Nα-Fmoc-NG,NG'-diethyl-L-homoarginine
EINECS	Contact for details

Quality Control

Our Fmoc-L-Har(Et)2-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric integrity. Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with research and cGMP-grade material standards for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	-15.0° to -18.0° (c=1, DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.