Description

6-Cyano-2,3-difluoroaniline (3,4-difluoroanthranilonitrile) is a high-value, multi-functional aromatic building block characterized by its cyano and difluoro-substituted aniline structure. This compound is essential for introducing both fluorine atoms and a nitrile functional group into target molecules, enabling fine-tuning of electronic properties, lipophilicity, and metabolic stability. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of advanced intermediates and active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly kinase inhibitors and other small-molecule therapeutics where fluorine substitution is critical for bioactivity.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the fluorine atoms to enhance compound stability and membrane permeability.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Fluorinated Dye & Pigment Intermediate: Employed in the synthesis of advanced colorants and imaging agents with improved lightfastness and chemical resistance.
• Cross-Coupling Reactions: The aniline and cyano groups make it a versatile substrate for palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination) to construct complex heterocyclic systems.

Basic Information

Product Name	6-Cyano-2,3-difluoroaniline / 3,4-Difluoroanthranilonitrile
CAS No.	1384265-40-0
Molecular Formula	C7H4F2N2
Molecular Weight	154.12 g/mol
Synonyms	3,4-Difluoro-2-aminobenzonitrile; 2-Amino-3,4-difluorobenzonitrile; 3,4-Difluoroanthranilic acid nitrile; 2,3-Difluoro-6-cyanoaniline; 6-Amino-2,3-difluorobenzonitrile; 1384265-40-0; 3,4-Difluoro-2-cyanobenzenamine
EINECS	Contact for details

Quality Control

Our 6-Cyano-2,3-difluoroaniline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to prevent oxidation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.