Description

4-Yn-9-Ylmethoxy]Carbonyl]-L-Lysine is a specialized, non-natural amino acid derivative designed for advanced bioconjugation and chemical biology research. This compound is a critical building block for the synthesis of peptide-based probes, drug conjugates, and materials science applications due to its unique alkyne and lysine-derived functional groups. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for developing targeted therapeutics and novel biomaterials.

Application

• Bioconjugation & Click Chemistry: The terminal alkyne group enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for labeling proteins, antibodies, and other biomolecules.
• Peptide & Protein Engineering: Serves as a modified lysine residue for introducing novel chemical handles into synthetic peptides and engineered proteins.
• ADC (Antibody-Drug Conjugate) Development: Used as a linker-payload component to create stable, site-specific conjugates for targeted cancer therapies.
• Proteomics Research: Acts as a chemical probe for activity-based protein profiling (ABPP) and studying enzyme function.
• Materials Science: Incorporation into polymers and hydrogels to create functionalized biomaterials with tailored properties.
• Diagnostic Reagent Synthesis: Key intermediate in the production of fluorescent or radioactive tags for imaging and detection assays.

Basic Information

Product Name	4-Yn-9-Ylmethoxy]Carbonyl]-L-Lysine
CAS No.	1384100-45-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Fmoc-Lys(N-4-pentynoyl)-OH; Nε-(4-Pentynoyl)-Nα-Fmoc-L-lysine; N-α-Fmoc-N-ε-(4-pentynoyl)-L-lysine; Fmoc-Lys(Pentynoyl)-OH; Fmoc-L-Lys(Nε-4-pentynoyl)-OH; (2S)-6-(4-Pentynoylamino)-2-[(9H-fluoren-9-ylmethoxy)carbonylamino]hexanoic acid; Alkyne-functionalized Fmoc-Lysine; Fmoc-Lys(Alkyne)-OH
EINECS	Contact for details

Quality Control

Our 4-Yn-9-Ylmethoxy]Carbonyl]-L-Lysine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee compliance with research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation and an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95.0%
Water Content (KF)	≤1.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.