Description

2-(tert-Butoxycarbonylamino)Pyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a protected amino group on a fused pyrazolopyrimidine scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel drug candidates. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of kinase inhibitors and other targeted small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitor programs.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Chemical Biology Probes: Serves as a precursor for creating labeled compounds used to study biological pathways and target engagement.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific molecule development.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant scale for clinical trial material production.

Basic Information

Product Name	2-(tert-Butoxycarbonylamino)Pyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid
CAS No.	1383056-73-2
Molecular Formula	C₁₂H₁₄N₄O₄
Molecular Weight	278.26 g/mol
Synonyms	Boc-Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid; 2-[(tert-Butoxycarbonyl)amino]pyrazolo[1,5-a]pyrimidine-3-carboxylic acid; tert-Butyl N-(3-carboxypyrazolo[1,5-a]pyrimidin-2-yl)carbamate; Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-; 2-(Boc-amino)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid; 1383056-73-2; 2-(N-Boc-amino)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 2-(tert-Butoxycarbonylamino)Pyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with complete batch traceability are provided to guarantee consistent quality and supply reliability for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.