Description

4,6-Diphenyl-2-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Pyrimidine is a high-value, organoboron-containing pyrimidine derivative that serves as a critical building block in modern synthetic chemistry. Its primary value lies in its role as a versatile Suzuki-Miyaura cross-coupling reagent, enabling the efficient construction of complex biaryl and heterobiaryl structures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries who require reliable, high-purity intermediates for drug discovery and advanced material development.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in constructing novel fungicides, herbicides, and insecticides with complex aromatic backbones.
• Organic Light-Emitting Diodes (OLEDs): Serves as a building block for electron-transport materials and host materials in emissive layers.
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs).
• Academic & R&D Laboratories: A fundamental reagent for methodological development in palladium-catalyzed cross-coupling reactions.
• Chemical Biology Probes: Used to create tagged molecules for studying biological pathways and protein interactions.

Basic Information

Product Name	4,6-Diphenyl-2-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Pyrimidine
CAS No.	1381862-91-4
Molecular Formula	C28H27BN2O2
Molecular Weight	434.34 g/mol
Synonyms	2-[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-4,6-diphenylpyrimidine; 4,6-Diphenyl-2-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyrimidine; 3-(4,6-Diphenylpyrimidin-2-yl)phenylboronic acid pinacol ester; Boronic acid, B-[3-(4,6-diphenyl-2-pyrimidinyl)phenyl]-, pinacol ester; 1381862-91-4
EINECS	Contact for details

Quality Control

Every batch of our 4,6-Diphenyl-2-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Pyrimidine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive cross-coupling applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by HPLC, NMR, and other relevant spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) for long-term storage to prevent hydrolysis of the boronic ester moiety. Keep the container tightly sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.