Description

(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-{4'-Phenyl-[1,1'-Biphenyl]-4-Yl}Propanoic Acid is a specialized, high-purity amino acid derivative designed for advanced research and pharmaceutical development. This compound is critical for the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control and functional group compatibility. It is primarily utilized by medicinal chemists and process development scientists in pharmaceutical R&D, agrochemical research, and advanced material science for creating novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block in the solid-phase peptide synthesis (SPPS) of novel therapeutic peptides and protein analogs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new drug candidates targeting various diseases.
• Bioconjugation: Serves as a linker or spacer molecule for attaching peptides to other biomolecules, polymers, or surfaces in biotech applications.
• Agrochemical Development: Employed in the synthesis of peptide-based bioactive compounds for crop protection and enhancement.
• Academic Research: A valuable reagent for universities and research institutes studying peptide folding, protein-protein interactions, and chemical biology.
• Process Development: Used in scaling up and optimizing synthetic routes for GMP production of peptide active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-{4'-Phenyl-[1,1'-Biphenyl]-4-Yl}Propanoic Acid
CAS No.	1381789-61-2
Molecular Formula	C36H27NO4
Molecular Weight	537.60 g/mol
Synonyms	Fmoc-Bip(4)-Phe-OH; Fmoc-4'-Phenyl-[1,1'-biphenyl]-4-yl-L-alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4'-(phenyl)[1,1'-biphenyl]-4-yl-L-alanine; Fmoc-4'-Phenylbiphenyl-4-ylalanine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-([1,1'-biphenyl]-4-yl)propanoic acid derivative; Fmoc-Biphenyl(4'-Ph)-Ala-OH; Nα-Fmoc-4'-(Phenyl)-L-biphenylalanine; A protected biphenylalanine derivative.
EINECS	Contact for details

Quality Control

Every batch of (2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-{4'-Phenyl-[1,1'-Biphenyl]-4-Yl}Propanoic Acid is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles are available for every lot and provided with shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake. For short-term use (under one week), storage at 2-8°C in a desiccator is acceptable.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.