Description

Fmoc-4-(3-Fluorophenyl)-L-Phenylalanine CAS NO 1380437-41-1 is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is a critical building block for the development of novel peptide-based pharmaceuticals and research tools, offering precise structural control. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on drug discovery and proteomics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptides, particularly those requiring fluorinated aromatic side chains for enhanced bioactivity or stability.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the research and development of therapeutic peptides targeting GPCRs, enzymes, and other biological receptors.
• Peptidomimetic Design: Used to incorporate fluorinated phenylalanine analogs into peptide backbones to improve metabolic stability, membrane permeability, and binding affinity.
• Chemical Biology Probes: Enables the synthesis of labeled or modified peptides for studying protein-protein interactions, enzyme mechanisms, and cellular signaling pathways.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse peptide libraries for high-throughput screening in drug discovery campaigns.
• Academic & Industrial Research: Supports fundamental research in medicinal chemistry, biochemistry, and material science where tailored peptide sequences are required.

Basic Information

Product Name	Fmoc-4-(3-Fluorophenyl)-L-Phenylalanine
CAS No.	1380437-41-1
Molecular Formula	C30H24FNO4
Molecular Weight	481.52 g/mol
Synonyms	Fmoc-3-Fluoro-L-biphenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-(3-fluorophenyl)-L-phenylalanine; Fmoc-4-(3-Fluorophenyl)-L-Phe-OH; (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-[4-(3-fluorophenyl)phenyl]propanoic acid; Fmoc-L-4-(3-Fluorophenyl)Phe; Fmoc-3'-Fluoro-L-biphenyl-4-ylalanine; Nα-Fmoc-4-(3-fluorophenyl)-L-phenylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-4-(3-Fluorophenyl)-L-Phenylalanine is manufactured under strict quality control protocols to ensure consistency and high purity suitable for sensitive research and development applications. Each batch is analyzed to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) detailing HPLC purity, chiral purity, and other relevant specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.