Description

N6-(2-Carboxyacetyl)-L-Lysine is a chemically modified derivative of the essential amino acid L-lysine, featuring a carboxyacetyl group on its ε-amino side chain. This specific functionalization makes it a valuable building block and intermediate in advanced pharmaceutical research and peptide synthesis. It is particularly relevant for scientists and manufacturers in the fields of bioconjugation, prodrug development, and the creation of novel therapeutic agents. The compound's structure allows for precise chemical modifications, enabling the development of targeted bioactive molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for oncology and metabolic diseases.
• Peptide Synthesis: Used as a modified amino acid residue in solid-phase and solution-phase peptide synthesis to introduce specific functional handles or alter peptide properties.
• Bioconjugation Chemistry: Serves as a linker or spacer molecule for attaching drugs, dyes, or other functional groups to proteins, antibodies, or nanoparticles.
• Prodrug Design: Employed in the design of prodrugs where the carboxyacetyl moiety can be cleaved enzymatically to release the active drug molecule.
• Biochemical Research: Utilized as a tool compound in enzymatic studies and metabolic pathway investigations involving lysine modification.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.

Basic Information

Product Name	N6-(2-Carboxyacetyl)-L-Lysine
CAS No.	1380412-92-9
Molecular Formula	C9H16N2O5
Molecular Weight	232.23 g/mol
Synonyms	Nε-(2-Carboxyacetyl)-L-lysine; N6-Carboxyacetyl-L-lysine; L-Lysine, N6-(carboxyacetyl)-; (2S)-2-Amino-6-[[(2-carboxyacetyl)amino]hexanoic acid; 2-[(2-Carboxyacetyl)amino]-6-aminohexanoic acid; ε-Carboxyacetyl-L-lysine; Lys(Carboxyacetyl)
EINECS	Contact for details

Quality Control

Our N6-(2-Carboxyacetyl)-L-Lysine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the stringent requirements for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.