Description

(S)-1-(2-Chloro-Pyrimidin-4-Yl)-Pyrrolidin-3-Ol is a high-purity chiral building block featuring a pyrimidine core, which is critical for constructing complex molecular architectures. This compound matters as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs), enabling the development of targeted therapeutics. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the production of novel drug candidates.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon in the research and development of new drug molecules, particularly in oncology and antiviral therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel bioactive compounds.
• Process Chemistry: Serves as a defined starting material or intermediate in the scale-up and commercial synthesis of Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Utilized in chiral pool synthesis and the construction of enantiomerically pure complex molecules due to its defined (S)-configuration.
• Agrochemical Research: Potential application as an intermediate in the development of advanced, targeted agrochemicals.

Basic Information

Product Name	(S)-1-(2-Chloro-Pyrimidin-4-Yl)-Pyrrolidin-3-Ol
CAS No.	1379439-07-2
Molecular Formula	C9H10ClN3O
Molecular Weight	211.65 g/mol
Synonyms	(S)-1-(2-Chloropyrimidin-4-yl)pyrrolidin-3-ol; (3S)-1-(2-Chloro-4-pyrimidinyl)-3-pyrrolidinol; (S)-3-Hydroxy-1-(2-chloropyrimidin-4-yl)pyrrolidine; 1379439-07-2; (S)-1-(2-Chloro-4-pyrimidinyl)pyrrolidin-3-ol; (S)-1-(2-Chloro-pyrimidin-4-yl)-pyrrolidin-3-ol; Pyrrolidin-3-ol, 1-(2-chloro-4-pyrimidinyl)-, (3S)-
EINECS	Contact for details

Quality Control

Our (S)-1-(2-Chloro-Pyrimidin-4-Yl)-Pyrrolidin-3-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.