Description

4-(1,1-Difluoroethyl)Aniline is a specialized fluorinated aniline derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the unique reactivity and electronic properties imparted by the difluoroethyl group, enabling the construction of complex molecular architectures. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients.

Application

This fluorinated aniline is a versatile synthon used in various high-value chemical syntheses.

• Pharmaceutical Intermediate: Key precursor for the synthesis of active pharmaceutical ingredients (APIs), especially those requiring fluorinated motifs to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Building block for developing new-generation herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & Electronic Materials: Used in the research and production of fluorinated compounds for electronic applications, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Advanced Polymer Chemistry: Serves as a monomer or modifier in the synthesis of specialty polymers with tailored thermal, chemical, or surface properties.
• Organic Synthesis & Research: A valuable reagent in academic and industrial R&D for constructing complex molecules, exploring new reaction pathways, and creating compound libraries for screening.

Basic Information

Product Name	4-(1,1-Difluoroethyl)Aniline
CAS No.	1379282-27-5
Molecular Formula	C8H9F2N
Molecular Weight	157.16 g/mol
Synonyms	4-(1,1-Difluoroethyl)benzenamine; 4-(1,1-Difluoroethyl)phenylamine; 1-(4-Aminophenyl)-1,1-difluoroethane; Benzenamine, 4-(1,1-difluoroethyl)-; α,α-Difluoro-p-ethylideneaniline; p-(1,1-Difluoroethyl)aniline
EINECS	Contact for details

Quality Control

Our 4-(1,1-Difluoroethyl)Aniline is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.