Description

Sugammadex CAS NO 1378831-29-8 is a modified γ-cyclodextrin specifically engineered as a selective relaxant binding agent (SRBA). This compound is critically important in modern anesthesia for its ability to rapidly and effectively reverse neuromuscular blockade induced by rocuronium or vecuronium. It is an essential pharmaceutical active ingredient for manufacturers developing injectable solutions used in hospital and surgical settings to enhance patient safety and procedural efficiency.

Application

• Primary Pharmaceutical Ingredient: Used as the active pharmaceutical ingredient (API) in the formulation of injectable reversal agents for neuromuscular blocking drugs.
• Anesthesia Reversal: Specifically formulated to reverse the effects of steroidal non-depolarizing neuromuscular blocking agents, namely rocuronium and vecuronium bromide.
• Surgical Procedure Facilitation: Enables rapid recovery of muscle function post-surgery, allowing for faster extubation and improved operating room turnover.
• Critical Care Medicine: Used in emergency and intensive care settings for the urgent reversal of deep neuromuscular blockade.
• Research & Development: Serves as a key reference standard and intermediate in pharmaceutical R&D for developing new anesthetic adjuvants.
• Generic Drug Manufacturing: A critical component for companies producing generic versions of neuromuscular blockade reversal drugs.

Basic Information

Item	Details
Product Name	Sugammadex
CAS No.	1378831-29-8
Molecular Formula	C72H104Na8O48S8
Molecular Weight	2177.62 g/mol
Synonyms	Org 25969; Bridion (Brand Name); Sodium 6-perdeoxy-6-per(2-carboxyethyl)thio-γ-cyclodextrin; γ-Cyclodextrin, 6A,6B,6C,6D,6E,6F,6G,6H-octakis(2-carboxyethylthio)-, octasodium salt; Selective Relaxant Binding Agent; Sugammadex Sodium; (2-Carboxyethyl)thio-γ-cyclodextrin, octasodium salt
EINECS	Contact for details

Quality Control

Our Sugammadex is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use. We provide full traceability and support regulatory filings. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request, and the material can be supplied to meet relevant pharmacopeial standards (e.g., USP, EP) as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. The original container should be kept sealed under an inert atmosphere when not in use to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Bacterial Endotoxins	<5.0 EU/mg
Microbial Enumeration	Meets Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.