Description

Phenol, 2,4-Difluoro-5-Methyl- is a fluorinated phenolic derivative, a high-value synthetic intermediate prized for its unique substitution pattern. This compound is critical for introducing specific steric and electronic properties into target molecules, enabling advanced material and pharmaceutical development. It is primarily sought by research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides where the difluoromethylphenol moiety enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated mesogens and electron-transport materials, improving the performance and durability of display and lighting technologies.
• Polymer Modification: Incorporated as a monomer or additive to create specialty polymers with enhanced chemical resistance, thermal stability, and surface properties.
• Organic Synthesis & Catalysis: A versatile reagent in cross-coupling reactions and as a ligand precursor in organometallic catalysis for complex molecule construction.
• Academic & Contract Research: Essential for medicinal chemistry programs and material science research in universities and CROs exploring fluorinated compound libraries.

Basic Information

Item	Details
Product Name	Phenol, 2,4-Difluoro-5-Methyl-
CAS No.	1378584-21-4
Molecular Formula	C7H6F2O
Molecular Weight	144.12 g/mol
Synonyms	2,4-Difluoro-5-methylphenol; 5-Methyl-2,4-difluorophenol; 3,5-Difluoro-4-hydroxytoluene; 2,4-Difluoro-5-methyl hydroxybenzene; 4-Hydroxy-3,5-difluorotoluene; 5-Methyl-2,4-difluoro-1-hydroxybenzene; Difluoromethylphenol (isomer)
EINECS	Contact for details

Quality Control

Every batch of Phenol, 2,4-Difluoro-5-Methyl- is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure the material meets the precise requirements of your synthetic pathway. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents, bases, and acid chlorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.