Description

6-Bromo-2-(trifluoromethyl)pyrimidin-4-amine is a high-value, multi-functional pyrimidine derivative that serves as a critical building block in advanced organic synthesis. Its molecular structure, featuring both bromo and trifluoromethyl substituents, makes it an indispensable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the trifluoromethyl group often enhances biological activity and stability.
• Material Science Research: Serves as a precursor for the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological systems.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to form more complex structures.
• Fluorinated Compound Libraries: A valuable building block for creating diverse libraries of fluorinated compounds for high-throughput screening in drug discovery.

Basic Information

Product Name	6-Bromo-2-(trifluoromethyl)pyrimidin-4-amine
CAS No.	1378259-23-4
Molecular Formula	C5H4BrF3N3
Molecular Weight	240.01 g/mol
Synonyms	4-Amino-6-bromo-2-(trifluoromethyl)pyrimidine; 6-Bromo-2-(trifluoromethyl)-4-pyrimidinamine; 2-(Trifluoromethyl)-6-bromopyrimidin-4-amine; 6-Bromo-2-trifluoromethylpyrimidin-4-ylamine; 4-Pyrimidinamine, 6-bromo-2-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 6-Bromo-2-(trifluoromethyl)pyrimidin-4-amine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and process development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions (e.g., nitrogen or argon atmosphere) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.