Description

(E)-3-(2-Fluorophenyl)-2-Methylacrylaldehyde is a high-purity fluorinated aromatic aldehyde building block. This compound is valued for its role as a key synthetic intermediate in the development of advanced pharmaceutical and agrochemical molecules. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced bioactivity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and advanced polymers with specific electronic or optical properties.
• Custom Synthesis and Contract Manufacturing: A vital building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	(E)-3-(2-Fluorophenyl)-2-Methylacrylaldehyde
CAS No.	1375800-37-5
Molecular Formula	C10H9FO
Molecular Weight	164.18 g/mol
Synonyms	(E)-3-(2-Fluorophenyl)-2-methylprop-2-enal; 2-Fluoro-α-methylcinnamaldehyde; (E)-2-Methyl-3-(2-fluorophenyl)acrylaldehyde; 3-(2-Fluorophenyl)-2-methylacrolein; (E)-3-(2-Fluorophenyl)-2-methylpropenal; 2-Fluorophenyl methylacrolein; (E)-2-Fluoro-α-methylcinnamaldehyde
EINECS	Contact for details

Quality Control

Our (E)-3-(2-Fluorophenyl)-2-Methylacrylaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory filings (e.g., DMF, CMC).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening sealed containers to maintain purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.