Description

Iloperidone n-Oxide is a key pharmaceutical intermediate and metabolite of the atypical antipsychotic drug Iloperidone. This compound is of significant importance for research and development in neuropharmacology, particularly in the study of drug metabolism, pharmacokinetics, and the synthesis of related active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in the development and quality control of central nervous system (CNS) therapeutics.

Application

• Pharmaceutical Intermediate: Critical for the synthesis and scale-up production of Iloperidone and its derivative compounds.
• Metabolite Reference Standard: Serves as an essential analytical standard in bioanalytical studies for quantifying Iloperidone metabolites in biological matrices.
• Pharmacology Research: Used in preclinical and clinical research to understand the metabolic pathways, efficacy, and safety profile of Iloperidone.
• Impurity Profiling: Employed in quality control laboratories to identify, characterize, and control process-related impurities in Iloperidone API batches.
• Method Development & Validation: A vital component for developing and validating HPLC, LC-MS, and other chromatographic methods in pharmaceutical analysis.

Basic Information

Product Name	Iloperidone n-Oxide
CAS No.	1375651-09-4
Molecular Formula	C24H27FN2O4
Molecular Weight	426.48 g/mol
Synonyms	1-[4-[3-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]propoxy]-3-methoxyphenyl]ethanone N-Oxide; Iloperidone N-Oxide; Iloperidone Metabolite; Fanapt N-Oxide; 4'-[3-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3'-methoxyacetophenone 1-Oxide
EINECS	Contact for details

Quality Control

Our Iloperidone n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and related substances. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and pharmaceutical industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.