Description

3-[4-(Trifluoromethyl)Phenyl]Prop-2-Yn-1-Amine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its amine hydrochloride salt form and a terminal alkyne functional group attached to a trifluoromethylphenyl moiety. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of targeted small molecule therapeutics. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate this specific pharmacophore into novel active compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, inflammatory diseases, and oncology.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its versatile alkyne handle for click chemistry and amide bond formation.
• Agrochemical Synthesis: Serves as a precursor in the development of novel herbicides, fungicides, or insecticides that leverage the physicochemical properties imparted by the trifluoromethyl group.
• Chemical Biology Probes: Employed in the creation of activity-based probes or affinity tags for studying enzyme function and protein interactions.
• Material Science Precursor: Can be utilized in the development of advanced organic materials, such as polymers or liquid crystals, where its rigid aromatic and alkyne structure is beneficial.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis organizations (CSOs) and CDMOs producing bespoke compounds for client R&D programs.

Basic Information

Product Name	3-[4-(Trifluoromethyl)Phenyl]Prop-2-Yn-1-Amine Hydrochloride
CAS No.	1375472-81-3
Molecular Formula	C10H7ClF3N
Molecular Weight	233.61 g/mol
Synonyms	4-(Trifluoromethyl)phenylpropiolylamine hydrochloride; 1-(4-Trifluoromethylphenyl)-2-propyn-1-amine hydrochloride; 3-[4-(Trifluoromethyl)phenyl]prop-2-yn-1-amine HCl; 4-(Trifluoromethyl)phenylpropagylamine hydrochloride; 3-(4-Trifluoromethylphenyl)prop-2-yn-1-amine hydrochloride; 1-Amino-3-[4-(trifluoromethyl)phenyl]-2-propyne hydrochloride; (4-Trifluoromethylphenyl)propargylamine hydrochloride
EINECS	Contact for details

Quality Control

Our 3-[4-(Trifluoromethyl)Phenyl]Prop-2-Yn-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.