Description

(R)-(+)-1-Fmoc-4-Oxopiperidine-2-Carboxylic Acid CAS NO 1375078-38-8 is a high-purity, chiral building block featuring both a carboxylic acid and a protected amine (Fmoc) group on a piperidinone scaffold. This compound is critically important for the synthesis of complex, stereochemically defined molecules, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing peptide mimetics, protease inhibitors, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and antiviral targets.
• Peptidomimetic Synthesis: Used to incorporate constrained, non-natural amino acid residues into peptide chains to enhance metabolic stability and binding affinity.
• Protease Inhibitor Development: Serves as a core scaffold for designing inhibitors of various proteases due to its piperidinone structure.
• Combinatorial Chemistry: Employed in solid-phase and solution-phase parallel synthesis libraries for high-throughput screening.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in catalytic asymmetric transformations to construct complex chiral centers.
• Chemical Biology Probes: Incorporated into molecular probes for studying enzyme function and protein-protein interactions.

Basic Information

Product Name	(R)-(+)-1-Fmoc-4-Oxopiperidine-2-Carboxylic Acid
CAS No.	1375078-38-8
Molecular Formula	C22H21NO5
Molecular Weight	379.41 g/mol
Synonyms	(R)-1-((9H-Fluoren-9-yl)methoxy)carbonyl)-4-oxopiperidine-2-carboxylic acid; Fmoc-4-oxo-D-pipecolic acid; 1-Fmoc-4-oxo-(R)-piperidine-2-carboxylic acid; (R)-1-Fmoc-4-oxopiperidine-2-carboxylic acid; (2R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-oxopiperidine-2-carboxylic acid; Fmoc-D-4-oxopipecolic acid; 4-Oxo-1-Fmoc-(R)-pipecolinic acid
EINECS	Contact for details

Quality Control

Our (R)-(+)-1-Fmoc-4-Oxopiperidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.