Description

6-Bromo-4H-Cyclopenta[D]Pyrimidin-4-One is a high-purity, advanced pharmaceutical intermediate and heterocyclic building block of significant commercial interest. Its core value lies in its role as a versatile synthon for constructing complex molecular architectures, particularly in medicinal chemistry and drug discovery programs. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of kinase inhibitors and other targeted therapeutic agents.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for novel drug candidates.
• Agrochemical Development: Serves as a precursor for creating new active ingredients with potential herbicidal or pesticidal activity.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target validation.
• Organic Synthesis: A versatile electrophile for cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution.

Basic Information

Product Name	6-Bromo-4H-Cyclopenta[D]Pyrimidin-4-One
CAS No.	1375069-40-1
Molecular Formula	C7H3BrN2O
Molecular Weight	211.02 g/mol
Synonyms	6-Bromocyclopenta[d]pyrimidin-4(1H)-one; 6-Bromo-1H-cyclopenta[d]pyrimidin-4-one; 6-Bromo-4H-cyclopenta[d]pyrimidin-4-one; 6-Bromo-4-oxo-4H-cyclopenta[d]pyrimidine; 1375069-40-1; 6-Bromo-cyclopenta[d]pyrimidin-4-one; 6-Bromo-4H-cyclopentapyrimidin-4-one
EINECS	Contact for details

Quality Control

Our 6-Bromo-4H-Cyclopenta[D]Pyrimidin-4-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our commitment to quality supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.