Description

4-Chloro-2-Methoxy-5-Nitropyrimidine is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in its versatile reactivity, where the chloro, methoxy, and nitro substituents offer distinct sites for selective functionalization, enabling the construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of nucleoside analogs, kinase inhibitors, and other biologically active heterocyclic compounds.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Material Science: Potential building block for the synthesis of specialty polymers, ligands, and advanced organic materials.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	4-Chloro-2-Methoxy-5-Nitropyrimidine
CAS No.	1375065-27-2
Molecular Formula	C5H4ClN3O3
Molecular Weight	189.56 g/mol
Synonyms	5-Nitro-4-chloro-2-methoxypyrimidine; 2-Methoxy-4-chloro-5-nitropyrimidine; 4-Chloro-2-methoxy-5-nitro-pyrimidine; Pyrimidine, 4-chloro-2-methoxy-5-nitro-; 1375065-27-2
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Methoxy-5-Nitropyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures the material is suitable for demanding applications in research and cGMP-compliant synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.