Description

Piperidine-4-Carboxylic Acid, 1-(2-Bromopyrimidin-5-Yl)-, Methyl Ester is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound is critical for medicinal chemistry research and the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor programs. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers requiring a reliable, high-purity intermediate for complex multi-step syntheses.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted small molecule drugs, especially protein kinase inhibitors.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies due to its versatile piperidine-pyrimidine scaffold.
• Chemical Biology Probes: Serves as a core structure for developing tool compounds and probes to study biological pathways.
• Agrochemical Synthesis: Potential intermediate in the research and development of new crop protection agents.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific novel chemical entities (NCEs).

Basic Information

Product Name	Piperidine-4-Carboxylic Acid, 1-(2-Bromopyrimidin-5-Yl)-, Methyl Ester
CAS No.	1375065-01-2
Molecular Formula	C11H12BrN3O2
Molecular Weight	298.14 g/mol
Synonyms	1-(2-Bromopyrimidin-5-yl)piperidine-4-carboxylic acid methyl ester; Methyl 1-(2-bromopyrimidin-5-yl)piperidine-4-carboxylate; 1-(2-Bromo-5-pyrimidinyl)-4-piperidinecarboxylic acid methyl ester; 4-Piperidinecarboxylic acid, 1-(2-bromopyrimidin-5-yl)-, methyl ester; 1375065-01-2; Methyl 1-(2-bromopyrimidin-5-yl)-4-piperidinecarboxylate
EINECS	Contact for details

Quality Control

Our Piperidine-4-Carboxylic Acid, 1-(2-Bromopyrimidin-5-Yl)-, Methyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.